A randomised, double-blind, placebo-controlled study in children showed that a supplement of the probiotic strains L. reuteri ATCC PTA 5289 and L. reuteri DSM 17938 significantly reduced days of fever and severity of pain in children with upper respiratory tract infections.
"Due to its anti-inflammatory effects, this combination of strains reduces both duration of fever and intensity of sore throat," says Pedro Gutiérrez-Castrellón, MD, MSc, DSc, Centre for Translational Research on Mother and Child Health, Hospital General Dr. Manuel Gea González, Mexico City, Mexico.
70 children between 6 months and 5 years with pharyngitis or tonsilitis were randomised to a probiotic supplement containing L. reuteri ATCC PTA 5289 and L. reuteri DSM 17938 or placebo, 5 drops twice a day for 10 days. The dose of the probiotic supplement was 4x10 CFU/day.
No fever from day two and less pain
The results showed that the children in the probiotic group had a significant reduction of fever, from day two and onwards, as well as a significant reduction of severity of sore throat.
"The importance of this study lies not only in the clinical impact observed but also in the reduction of related costs, which undoubtedly adds a significant value from a public health point of view, considering the frequency of acute respiratory infections observed in young children and the impact on their quality of life," says Pedro Gutiérrez-Castrellón.
"Upper respiratory tract infections are very common and a global public health problem. The positive results of this study should therefore be valuable for many parents and paediatricians - and for the numerous children in pain," says Isabelle Ducellier, CEO of BioGaia.
The study was published online 1 April 2021 in Beneficial Microbes (https://doi.org/10.3920/BM2020.0171). Study facts are found here (https://www.biogaia.com/wp-content/uploads/2021/04/Study-facts-Gutierrez-April-2021.pdf).
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